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KMID : 0381019930260030277
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Korean Journal of Nutrition
1993 Volume.26 No. 3 p.277 ~ p.285
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Effects of Dietary Calcium levels on the Reduction of Calcium Availability in Ovariectomized Osteoporosis Model Rats
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Abstract
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To investigate the effects of dietary calcium levels on the Ca metabolism in a rat model of ovarectomized osteoporosis, two studies were conducted. In Expt. I. five week-old female rats ovariectomized and fed a low Ca dite(0.06% Ca) for four
weeks
were
compared with rats fed a normal(0.53% Ca) or low Ca diet under the sham-operated condition. Ovariectomized rats showed a significant increase in body weight and food intake. In rats fed the low Ca diet, a remarkable decrease was shown regardless
of
ovariectomy in serum Ca concentration, breaking force of bones, Ca and phosphorus contents of bones, and apparent absorption and retention of Ca. furthermore the decrease of Ca contents of serum and bones in rats ovariectomized and fed the low Ca
diet
was similar to that in rats model of postmenopausal osteoporosis. In Expt. II. rats ovariectomized and fed on the low Ca diet for four weeks divided into three groups. Those given low Ca diet, normal Ca diet and high Ca diet (10.6%) respectively.
the
results indicated that supplementations of Ca at the intake level of 0.53% and 1.06% for 4 weeks tend to improve the relative Ca diet and high Ca diet (10.6%) respectively. Ths results indicated that supplementations of Ca at the intake level of
0.53%
and 10.6% for 4 weeks tend to improve the relative Ca deficiency shown in experimental rat model of ovariectomized osteoporosis.
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KEYWORD
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